A port city in northeastern Missouri, on the Mississippi River, the boyhood home of Mark Twain; population 17,432 (est. 2008). ( 247–182 bc ) , Carthaginian general. In the second Punic War he attacked Italy by crossing the Alps. He repeatedly defeated the Romans, although he failed to take Rome itself. After being recalled to Africa he was defeated at Zama by Scipio Africanus in 202.